Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide
MANF
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979757
Quick Overview for Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) Peptide (ABIN979757)
Target
MANF
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- EKICEKLKKK DSQICELKYD KQIDLSTVDL KKLRVKELKK ILDDWGETCK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MANF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) peptide
MANF Reactivity: Human, Dog, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
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Background
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MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of MANF gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors, however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
Alias Symbols: ARMET, ARP, MGC142148, MGC142150
Protein Size: 185 -
Molecular Weight
- 21 kDa
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Gene ID
- 7873
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NCBI Accession
- NM_006010, NP_006001
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UniProt
- A8K878
Target
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