Minichromosome Maintenance Complex Component 3 (MCM3) Peptide
MCM3
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN979895
Quick Overview for Minichromosome Maintenance Complex Component 3 (MCM3) Peptide (ABIN979895)
Target
MCM3
(Minichromosome Maintenance Complex Component 3 (MCM3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM3 antibody (Catalog #: ARP36645_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))
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Background
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MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Alias Symbols: HCC5, MGC1157, P1-MCM3, P1.h, RLFB
Protein Interaction Partner: MCM2,MCM2,MCM5,MCM5,MCM7,MCM7,CDC45,CDC5L,CDC6,CDC7,CDK2,DBF4,HAUS1,MCM10,MCM2,MCM3AP,MCM4,MCM5,MCM6,MCM7,ORC2L,ORC4L,ORC5L,PLK1,POLR2A,PPP2R1A,PPP2R1B,RAD52,STAT1,SUPT16H,CDC45,CDC6,CDC7,DBF4,ENSA,MCM2,MCM3AP,MCM5,MCM7,ORC2L,ORC4L,ORC5L,PAK2,PMS2,PNKP,PTP4A3,RPA2,SNCG,WDR8
Protein Size: 808 -
Molecular Weight
- 89 kDa
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Gene ID
- 4172
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NCBI Accession
- NM_002388, NP_002379
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UniProt
- P25205
Target
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