Minichromosome Maintenance Deficient 8 (MCM8) Peptide
MCM8
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN979907
Quick Overview for Minichromosome Maintenance Deficient 8 (MCM8) Peptide (ABIN979907)
Target
MCM8
(Minichromosome Maintenance Deficient 8 (MCM8))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM8 antibody (Catalog #: ARP36668_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))
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Background
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MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: C20orf154, MGC119522, MGC119523, MGC12866, MGC4816, REC, dJ967N21.5
Protein Interaction Partner: MCM4,MCM6,MCM7,CDC6,CDC6,MCM4,MCM6,MCM7,ORC2L,ORC2L
Protein Size: 840 -
Molecular Weight
- 94 kDa
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Gene ID
- 84515
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NCBI Accession
- NM_032485, NP_115874
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UniProt
- Q9UJA3
Target
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