Methionyl Aminopeptidase 2 (METAP2) Peptide
METAP2
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all METAP2 products
- METAP2 (Methionyl Aminopeptidase 2 (METAP2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-METAP2 antibody (Catalog #: ARP52266_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- METAP2 (Methionyl Aminopeptidase 2 (METAP2))
- Synonyms
- metap2 Peptide, MGC53792 Peptide, METAP2 Peptide, GB13458 Peptide, DDBDRAFT_0190923 Peptide, DDBDRAFT_0304991 Peptide, DDB_0190923 Peptide, DDB_0304991 Peptide, 4930584B20Rik Peptide, A930035J23Rik Peptide, AI047573 Peptide, AL024412 Peptide, AU014659 Peptide, Amp2 Peptide, Mnpep Peptide, p67 Peptide, p67eIF2 Peptide, MAP2 Peptide, MNPEP Peptide, wu:fb98h06 Peptide, zgc:66250 Peptide, methionyl aminopeptidase 2 L homeolog Peptide, methionyl aminopeptidase 2 Peptide, methionine aminopeptidase 2 Peptide, methionine aminopeptidase Peptide, methionyl aminopeptidase 2 S homeolog Peptide, methionyl aminopeptidase 2b Peptide, metap2.L Peptide, METAP2 Peptide, metap2 Peptide, LOC551771 Peptide, CAALFM_C604080WA Peptide, Metap2 Peptide, metap2.S Peptide, metap2b Peptide
- Background
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METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MAP2, MNPEP, p67, p67eIF2
Protein Interaction Partner: E2F4,CDC42,EIF2AK2,EIF2S3,MAPK1,MAPK3,RAC1,S100A4,EIF2AK2
Protein Size: 478 - Molecular Weight
- 53 kDa
- Gene ID
- 10988
- NCBI Accession
- NM_006838, NP_006829
- UniProt
- P50579
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