Methionyl Aminopeptidase 2 (METAP2) Peptide
METAP2
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN979997
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Methionyl Aminopeptidase 2 (METAP2) Peptide (ABIN979997)
Target
METAP2
(Methionyl Aminopeptidase 2 (METAP2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-METAP2 antibody (Catalog #: ARP52266_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- METAP2 (Methionyl Aminopeptidase 2 (METAP2))
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Background
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METAP2 is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site.This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MAP2, MNPEP, p67, p67eIF2
Protein Interaction Partner: E2F4,CDC42,EIF2AK2,EIF2S3,MAPK1,MAPK3,RAC1,S100A4,EIF2AK2
Protein Size: 478 -
Molecular Weight
- 53 kDa
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Gene ID
- 10988
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NCBI Accession
- NM_006838, NP_006829
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UniProt
- P50579
Target
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