Mitochondrial Ribosomal Protein L49 (MRPL49) (N-Term) Peptide
MRPL49
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980263
Quick Overview for Mitochondrial Ribosomal Protein L49 (MRPL49) (N-Term) Peptide (ABIN980263)
Target
MRPL49
(Mitochondrial Ribosomal Protein L49 (MRPL49))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- IMVTFRNQAS RPYSFYSSLI SYEEDQRQGA EPRKNFVKPN ETKTYFWKVQ
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MRPL49 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MRPL49 (Mitochondrial Ribosomal Protein L49 (MRPL49))
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Background
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This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Alias Symbols: C11orf4, L49mt, MGC10656, NOF, NOF1, MRP-L49
Protein Interaction Partner: ASGR2,CALR,CANX,F10,F2,F9,HSPA5,LMAN1,LRP1,MCFD2,PHYH,PROC,PROS1,VWF,CANX,F10,LMAN1,LRP1,PHYH,PROS1,VWF
Protein Size: 2351 -
Molecular Weight
- 79 kDa
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Gene ID
- 740
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NCBI Accession
- NM_004927, NP_004918
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UniProt
- Q13405
Target
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