5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) (N-Term) Peptide
MTRR
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980362
Quick Overview for 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) (N-Term) Peptide (ABIN980362)
Target
MTRR
(5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- YDLKTETAPL VVVVSTTGTG DPPDTARKFV KEIQNQTLPV DFFAHLRYGL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MTRR Antibody(ARP57657_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))
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Background
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Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: MGC129643, MSR, cblE
Protein Interaction Partner: MMAB
Protein Size: 725 -
Molecular Weight
- 80 kDa
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Gene ID
- 4552
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NCBI Accession
- NM_024010, NP_076915
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UniProt
- Q9UBK8
Target
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