Nuclear Factor, Interleukin 3 Regulated (NFIL3) Peptide
NFIL3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980664
Quick Overview for Nuclear Factor, Interleukin 3 Regulated (NFIL3) Peptide (ABIN980664)
Target
NFIL3
(Nuclear Factor, Interleukin 3 Regulated (NFIL3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NFIL3 antibody (Catalog #: ARP31177_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Nuclear Factor, Interleukin 3 Regulated (NFIL3) peptide
NFIL3 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NFIL3 (Nuclear Factor, Interleukin 3 Regulated (NFIL3))
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Background
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NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.
Alias Symbols: E4BP4, IL3BP1, NF-IL3A, NFIL3A
Protein Interaction Partner: CREB3,DR1,NFIL3,DR1
Protein Size: 462 -
Molecular Weight
- 51 kDa
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Gene ID
- 4783
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NCBI Accession
- NM_005384, NP_005375
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UniProt
- Q16649
Target
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