NF-kappa-B inhibitor beta (NFKBIB) Peptide
NFKBIB
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980675
Quick Overview for NF-kappa-B inhibitor beta (NFKBIB) Peptide (ABIN980675)
Target
NFKBIB
(NF-kappa-B inhibitor beta (NFKBIB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NFKBIB antibody (Catalog #: ARP34382_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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Background
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NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM].
Alias Symbols: IKBB, TRIP9
Protein Interaction Partner: IKBKB,MCC,RELA,RELA,BTRC,CD3EAP,CHUK,CUL1,IKBKB,IKBKG,KPNA2,LRPPRC,MCC,MTIF2,NFKB1,NFKB2,NFKBIA,NGFR,NKIRAS1,NKIRAS2,PDCD2,POLR1A,POLR1B,POLR1C,POLR1D,POLR1E,POLR2H,POLR2L,RASAL2,REL,RELA,RXRA,SKP1,BTRC,CHUK,IKBKB,NKIRAS1,REL,RELA,RXRA,Thrb
Protein Size: 356 -
Molecular Weight
- 38 kDa
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Gene ID
- 4793
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NCBI Accession
- NM_002503, NP_002494
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UniProt
- Q15653
Target
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