NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (N-Term) Peptide
NKIRAS1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980722
Quick Overview for NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1) (N-Term) Peptide (ABIN980722)
Target
NKIRAS1
(NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NKIRAS1 antibody (Catalog #: ARP55370_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NKIRAS1 (NFKB Inhibitor Interacting Ras-Like 1 (NKIRAS1))
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Background
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NKIRAS1 is an atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. NKIRAS1 may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Alias Symbols: KBRAS1, kappaB-Ras1
Protein Interaction Partner: ACVR1,BMPR1B,NFKBIA,NFKBIB,SMURF2,TGFBR1,NFKBIB
Protein Size: 192 -
Molecular Weight
- 22 kDa
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Gene ID
- 28512
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NCBI Accession
- NM_020345, NP_065078
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UniProt
- Q9NYS0
Target
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