Notch 1 (NOTCH1) (Middle Region) Peptide
NOTCH1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980807
Quick Overview for Notch 1 (NOTCH1) (Middle Region) Peptide (ABIN980807)
Target
Notch1 (NOTCH1)
(Notch 1 (NOTCH1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NOTCH1 antibody (Catalog #: ARP39295_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
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Background
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NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TAN1, hN1
Protein Interaction Partner: APBA1,SNW1,ADAM17,APBA1,BLOC1S1,CBL,CNTN1,DLL1,DLL4,DTX1,DTX2,EP300,FBXW7,FURIN,GFI1B,GSK3B,ITCH,JAG1,JAG2,KAT2A,KAT2B,LCK,LEF1,LFNG,MAML1,MAML2,MAML3,MEF2C,MFNG,NFKB1,NOTCH1,NOV,NUMB,NUMBL,PIK3CG,POFUT1,PSEN1,PSEN2,RBP3,RBPJ,REL,RELA,SMAD3,SNW1,WDR12,XIAP,XRCC6,YY1,CNTN1,DLL1,DTX1,FBXW7,GSK3B,Itch,JAG1,JAG2,LCK,LEF1,MAML1,MAML2,MAML3,NFKB1,NOTCH1,NOTCH3,NOV,NUMB,PIK3CA,PSEN1,RBPJ,RELA,SMAD3,SNW1,UBC,XRCC6,YY1
Protein Size: 2555 -
Molecular Weight
- 88 kDa
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Gene ID
- 4851
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NCBI Accession
- NM_017617, NP_060087
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UniProt
- P46531
Target
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