E3 SUMO-Protein Ligase NSE2 (NSMCE2) (Middle Region) Peptide
NSMCE2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980977
Quick Overview for E3 SUMO-Protein Ligase NSE2 (NSMCE2) (Middle Region) Peptide (ABIN980977)
Target
NSMCE2
(E3 SUMO-Protein Ligase NSE2 (NSMCE2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NSMCE2 antibody (Catalog #: ARP55690_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
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Background
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NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Alias Symbols: C8orf36, FLJ32440, MMS21, NSE2
Protein Size: 247 -
Molecular Weight
- 28 kDa
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Gene ID
- 286053
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NCBI Accession
- NM_173685, NP_775956
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UniProt
- Q96MF7
Target
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