E3 SUMO-Protein Ligase NSE2 (NSMCE2) Peptide
NSMCE2
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all NSMCE2 products
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- KFLALQSKNS DADFQNNEKF VQFKQQLKEL KKQCGLQADR EADGTEGVDE
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of NSMCE2 antibody,
Alternative Names: NSMCE2 control peptide, NSMCE2 antibody Blocking Peptide, Anti-NSMCE2 Blocking Peptide, Non-Smc Element 2 Mms21 Homolog Blocking Peptide, C8orf36 Blocking Peptide, FLJ32440 Blocking Peptide, MMS21 Blocking Peptide, NSE2 Blocking Peptide, NSMCE2, NSMCE-2, NSMCE 2, NSMCE-2 Blocking Peptide, NSMCE 2 Blocking Peptide - Purification
- Immunoaffinity chromatography
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Synonyms
- 1110014D18Rik Peptide, AI661537 Peptide, RGD1305156 Peptide, C8orf36 Peptide, MMS21 Peptide, NSE2 Peptide, ZMIZ7 Peptide, Non-SMC element 2 Peptide, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Peptide, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog Peptide, Smc5-6 complex non-SMC subunit 2 Peptide, Nsmce2 Peptide, NSMCE2 Peptide, nsmce2.L Peptide, nse2 Peptide
- Background
- NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
- Molecular Weight
- 28 kDa
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