8-Oxoguanine DNA Glycosylase (OGG1) (C-Term) Peptide
OGG1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981105
Quick Overview for 8-Oxoguanine DNA Glycosylase (OGG1) (C-Term) Peptide (ABIN981105)
Target
OGG1
(8-Oxoguanine DNA Glycosylase (OGG1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- AVPVDVHMWH IAQRDYSWHP TTSQAKGPSP QTNKELGNFF RSLWGPYAGW
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-OGG1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
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Background
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This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.
Alias Symbols: HMMH, HOGG1, MUTM, OGH1
Protein Interaction Partner: CHGB,OGG1,PRKCA,XRCC1,CHGB,PRKCA,SNRPF,XRCC1
Protein Size: 322 -
Molecular Weight
- 35 kDa
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Gene ID
- 4968
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NCBI Accession
- NM_016829, NP_058438
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UniProt
- O15527
Target
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