8-Oxoguanine DNA Glycosylase (OGG1) (C-Term) Peptide
OGG1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all OGG1 products
- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- AVPVDVHMWH IAQRDYSWHP TTSQAKGPSP QTNKELGNFF RSLWGPYAGW
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-OGG1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
- Background
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This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.
Alias Symbols: HMMH, HOGG1, MUTM, OGH1
Protein Interaction Partner: CHGB,OGG1,PRKCA,XRCC1,CHGB,PRKCA,SNRPF,XRCC1
Protein Size: 322 - Molecular Weight
- 35 kDa
- Gene ID
- 4968
- NCBI Accession
- NM_016829, NP_058438
- UniProt
- O15527
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