Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) Peptide
P4HB
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN981289
Quick Overview for Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) Peptide (ABIN981289)
Target
P4HB
(Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-P4HB antibody (Catalog #: ARP48150_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
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Background
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P4HB is the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DSI, ERBA2L, GIT, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB, P4Hbeta
Protein Interaction Partner: CD1D,COL10A1,COL1A1,COL1A2,EIF2S1,ERO1L,ERO1LB,FEZ1,P4HA2,P4HA3,P4HB,PRNP,PTN,TG,UBQLN1,YWHAG,CD2BP2,CUL2,EIF4A2,ELF3,ERO1L,ERO1LB,FEZ1,P4ha2,PTN,PUF60,TG,TNFRSF14,TRIP6,UBQLN1
Protein Size: 508 -
Molecular Weight
- 55 kDa
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Gene ID
- 5034
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NCBI Accession
- NM_000918, NP_000909
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UniProt
- P07237
Target
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