Poly (ADP-Ribose) Polymerase 1 (PARP1) Peptide
PARP1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981356
Quick Overview for Poly (ADP-Ribose) Polymerase 1 (PARP1) Peptide (ABIN981356)
Target
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PARP1 antibody (Catalog #: ARP33754_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 662-1014) peptide
PARP1 Reactivity: Human Host: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
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Background
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PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Alias Symbols: C12orf6, PARP1
Protein Interaction Partner: GTPBP3,DCAF11,GTPBP3,LYZ,NUP98,OTUD4,RNF114
Protein Size: 1014 -
Molecular Weight
- 113 kDa
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Gene ID
- 57097
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NCBI Accession
- NM_001618, NP_001609
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UniProt
- P09874
Target
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