Paired Box 3 (PAX3) Peptide
PAX3
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN981386
Quick Overview for Paired Box 3 (PAX3) Peptide (ABIN981386)
Target
Paired Box 3 (PAX3)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PAX3 antibody (Catalog #: ARP32736_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Paired Box 3 (PAX3) peptide
PAX3 Reactivity: Human, Mouse, Rat, Cow Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Paired Box 3 (PAX3)
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Background
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PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma.This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2,13)(q35,q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Alias Symbols: WS1, WS3, CDHS, HUP2
Protein Interaction Partner: CIB1,DAXX,MEOX1,MEOX2,MITF,MSX1,PAX3,SOX10,SOX8,WWTR1,CNR1,DAXX,IPO13,IPO13,MEOX1,MEOX2,MSX1,POU3F2,PSMD4,RAD23B,Rad23b,SOX10,SOX10,TBP,UBC,Ubc
Protein Size: 479 -
Molecular Weight
- 53 kDa
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Gene ID
- 5077
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NCBI Accession
- NM_181457, NP_852122
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UniProt
- P23760
Target
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