phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B) (N-Term) Peptide
PDE6B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PDE6B products
- PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LSMPIVNKKE EIVGVATFYN RKDGKPFDEQ DEVLMESLTQ FLGWSVMNTD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PDE6B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PDE6B (phosphodiesterase 6B, CGMP-Specific, Rod, beta (PDE6B))
- Background
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Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CSNB3, CSNBAD2, PDEB, RP40, rd1
Protein Size: 575 - Molecular Weight
- 63 kDa
- Gene ID
- 5158
- NCBI Accession
- NM_001145292, NP_001138764
- UniProt
- E7ETT3
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