Peroxisomal Biogenesis Factor 5 (PEX5) (Middle Region) Peptide
PEX5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981605
Quick Overview for Peroxisomal Biogenesis Factor 5 (PEX5) (Middle Region) Peptide (ABIN981605)
Target
PEX5
(Peroxisomal Biogenesis Factor 5 (PEX5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PEX5 antibody (Catalog #: ARP56102_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PEX5 (Peroxisomal Biogenesis Factor 5 (PEX5))
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Background
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PEX5 binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD).
Alias Symbols: PTS1R, PXR1, PTS1-BP
Protein Interaction Partner: PEX12,PEX14,AGXT,ATM,DDO,HSPA1A,PDZK1,PEX10,PEX12,PEX13,PEX14,PEX7,SCARB1,SIRT3,SNUPN,SSTR5,ATM,CAT,DDO,PDZK1,PEX10,PEX12,PEX13,PEX14,PEX7,SIRT3,SNUPN
Protein Size: 631 -
Molecular Weight
- 70 kDa
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Gene ID
- 5830
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NCBI Accession
- NM_000319, NP_000310
Target
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