Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide
PIN1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981770
Quick Overview for Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (N-Term) Peptide (ABIN981770)
Target
PIN1
(Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- RPSGNSSSGG KNGQGEPARV RCSHLLVKHS QSRRPSSWRQ EKITRTKEEA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PIN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) peptide
PIN1 Reactivity: Human, Rat, Mouse, Dog Host: Synthetic BP, Imm
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 22-255), (Extracellular Domain) peptidePIN1 Reactivity: Human Host: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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Background
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Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: DOD, UBL5
Protein Interaction Partner: CCND1,CDC27,PKMYT1,PLK1,RAF1,TP73,TP73,APP,BCL2,CCNB1,CCNE1,CDC25C,CDC27,CDK1,CDK9,CHPF,CSNK2A1,CSNK2A2,CSNK2B,CTNNB1,DAB2,DDX24,FASLG,GGA2,GPAA1,GPHN,JUN,KIF20B,KLHL20,LEPR,MAPT,MDFI,MTFR1,NCOA3,NEK6,NFATC2,NONO,PKMYT1,PLK1,POLR2A,PTOV1,PTPN1,RAB4A,RAF1,
Protein Size: 163 -
Molecular Weight
- 18 kDa
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Gene ID
- 5300
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NCBI Accession
- NM_006221, NP_006212
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UniProt
- Q13526
Target
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