PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (Middle Region) Peptide
PMS2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981896
Quick Overview for PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (Middle Region) Peptide (ABIN981896)
Target
PMS2
(PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PMS2 antibody (Catalog #: ARP56117_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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Background
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PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.
Alias Symbols: HNPCC4, PMS2CL, PMSL2
Protein Interaction Partner: EXO1,MLH1,EXO1,MLH1,AIFM1,ATAD3A,BRCA2,BRIP1,COPB1,COPG,COPG2,CYLD,DDB1,EXO1,KPNA2,KPNB1,MCM3,MLH1,MMS19,MSH2,MSH3,MSH6,MTMR15,NSUN2,PCNA,PIK3C2A,PPP2CA,PRKDC,PSD2,PSD3,PSMC1,PSMC2,PSMC3,PSMC6,PSMD5,RFC2,RUVBL1,RUVBL2,SMARCA4,UBC,UBR5,XPO1
Protein Size: 862 -
Molecular Weight
- 96 kDa
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Gene ID
- 5395
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NCBI Accession
- NM_000535, NP_000526
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UniProt
- P54278
Target
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