Presenilin 1 (PSEN1) (Middle Region) Peptide
PSEN1
Reactivity: Human
Host: Synthetic
BP, WB, IHC, IP
Catalog No. ABIN982321
Quick Overview for Presenilin 1 (PSEN1) (Middle Region) Peptide (ABIN982321)
Target
Presenilin 1 (PSEN1)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
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Protein Region
- Middle Region
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Sequence
- EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSEN1 Antibody(ARP58941_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Presenilin 1 (PSEN1)
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Background
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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Alias Symbols: AD3, FAD, PS1, S182, PS-1
Protein Interaction Partner: APH1A,APP,APP,APP,APP,CTNNB1,CTNND2,NCSTN,STX1A,STX5,CASP1,CASP3,CASP4,CASP7,APBA1,APH1A,APH1B,APP,BACE1,BCL2,BCL2L1,CASP1,CASP3,CASP4,CASP6,CASP7,CASP8,CDH1,CDK5,CIB1,CTNNA1,CTNNB1,CTNND1,CTNND2,DLL1,DOCK3,EFNB2,ERN1,FBXW7,FLNA,FLNB,GDI1,GFAP,GSK3B,HERPU
Protein Size: 467 -
Molecular Weight
- 53 kDa
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Gene ID
- 5663
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NCBI Accession
- NM_000021, NP_000012
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UniProt
- P49768
Target
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