Presenilin 2 (Alzheimer Disease 4) (PSEN2) Peptide
PSEN2
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN982322
Quick Overview for Presenilin 2 (Alzheimer Disease 4) (PSEN2) Peptide (ABIN982322)
Target
Presenilin 2 (PSEN2)
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSEN2 antibody (Catalog #: ARP44289_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Presenilin 2 (Alzheimer Disease 4) (PSEN2) peptide
PSEN2 Host: Synthetic BP, WB, IHC
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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Background
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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
Alias Symbols: AD3L, AD4, PS2, STM2, CMD1V
Protein Interaction Partner: APH1A,APH1B,APP,BCL2L1,CAPN1,CASP1,CASP3,CASP6,CASP7,CASP8,CFLAR,CIB1,CSNK1A1,CSNK1D,CSNK2A1,CTNNB1,CTNND2,DOCK3,FHL2,FLNA,FLNB,ICAM5,KCNIP3,KCNIP4,METTL2A,NCSTN,NOTCH1,NOTCH2,NOTCH3,NOTCH4,PSENEN,RAB11A,SRI,UBQLN1,APBA1,APBA2,APBA3,APH1A,APP,BCL2L1,CAPN1,CIB1,FHL2,FLNB,GFAP,ICAM5,KCNIP3,KCNIP4,NCSTN,PSEN1,PSENEN,SRI,UBC,UBQLN1
Protein Size: 448 -
Molecular Weight
- 49 kDa
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Gene ID
- 5664
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NCBI Accession
- NM_000447, NP_000438
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UniProt
- P49810
Target
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