Pancreas Specific Transcription Factor, 1a (PTF1A) (N-Term) Peptide
PTF1A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982418
Quick Overview for Pancreas Specific Transcription Factor, 1a (PTF1A) (N-Term) Peptide (ABIN982418)
Target
PTF1A
(Pancreas Specific Transcription Factor, 1a (PTF1A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTF1A antibody (Catalog #: ARP32531_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))
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Background
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PTF1A is a pancreas specific transcription factor. Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor PTF1A-p48 in the development of both exocrine and endocrine pancreas. This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PTF1-p48, bHLHa29
Protein Interaction Partner: TCF12
Protein Size: 328 -
Molecular Weight
- 35 kDa
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Gene ID
- 256297
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NCBI Accession
- NM_178161, NP_835455
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UniProt
- Q7RTS3
Target
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