Protein-tyrosine Phosphatase 1C (PTPN6) (Middle Region) Peptide
PTPN6
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982456
Quick Overview for Protein-tyrosine Phosphatase 1C (PTPN6) (Middle Region) Peptide (ABIN982456)
Target
SHP1 (PTPN6)
(Protein-tyrosine Phosphatase 1C (PTPN6))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- WEEFESLQKQ EVKNLHQRLE GQRPENKGKN RYKNILPFDH SRVILQGRDS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PTPN6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
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Background
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
Alias Symbols: HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Protein Interaction Partner: CAV1,ABL1,ACTN1,ACTN4,BCR,BLNK,BTLA,C6orf25,CAV1,CBL,CD22,CD247,CD300LF,CD33,CD5,CD72,CD79A,CD79B,CEACAM1,CLEC4A,CSF2RB,CTNNB1,CTNND1,CUZD1,CXCR4,DOK1,EGFR,EPOR,ESR1,FAS,FCGR2B,FLT3,GAB2,GHR,GRB2,HOXA10,IFNAR1,IL2RB,IL4R,IL6ST,INSR,IRS2,IRS4,JAK1,JAK2,JAK
Protein Size: 595 -
Molecular Weight
- 65 kDa
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Gene ID
- 5777
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NCBI Accession
- NM_002831, NP_002822
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UniProt
- P29350
Target
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