Poly-U Binding Splicing Factor 60KDa (PUF60) Peptide
PUF60
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all PUF60 products
- PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PUF60 antibody (Catalog #: ARP40759_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PUF60 (Poly-U Binding Splicing Factor 60KDa (PUF60))
- Background
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PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription.The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
Alias Symbols: FIR, FLJ31379, RoBPI, SIAHBP1
Protein Interaction Partner: CD101,CHD3,FUBP1,LOH12CR1,PCBP1,PPP1R16A,PUF60,SAP30BP,SRSF11,U2AF2,VIM,YWHAG,CD2BP2,CHD3,DDX3X,ELAC2,EWSR1,G3BP1,GPN1,HNRNPA3,HNRNPC,HNRNPL,IGF2BP1,IGF2BP2,IGF2BP3,ILK,KHSRP,LOH12CR1,MOV10,OLA1,P4HB,PABPC1,PABPC4,PPP1R16A,PUF60,RNMTL1,RNPS1,SAP30BP,SARS2,SF3A2,SF3A3,SF3B1,SRSF11,SSB,STOM,SYNCRIP,TROVE2,TTN,U2AF2,UGP2,VIM
Protein Size: 542 - Molecular Weight
- 58 kDa
- Gene ID
- 22827
- NCBI Accession
- NM_014281, NP_055096
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