Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (N-Term) Peptide
PVRL1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982488
$160.46
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100 μg
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Quick Overview for Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) (N-Term) Peptide (ABIN982488)
Target
PVRL1
(Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- QLNLTVMAKP TNWIEGTQAV LRAKKGQDDK VLVATCTSAN GKPPSVVSWE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PVRL1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1) peptide
PVRL1 Host: Synthetic BP, WB, IHC
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))
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Background
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This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Alias Symbols: CD111, CLPED1, ED4, HIgR, HVEC, MGC142031, MGC16207, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1
Protein Size: 517 -
Molecular Weight
- 57 kDa
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Gene ID
- 5818
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NCBI Accession
- NM_002855, NP_002846
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UniProt
- Q15223
Target
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