E3 ubiquitin-protein ligase RAD18 (RAD18) (Middle Region) Peptide
RAD18
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982601
$160.46
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100 μg
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Quick Overview for E3 ubiquitin-protein ligase RAD18 (RAD18) (Middle Region) Peptide (ABIN982601)
Target
RAD18
(E3 ubiquitin-protein ligase RAD18 (RAD18))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQCD ALHPKSAAEI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RAD18 Antibody(ARP43267_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))
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Background
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RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
Alias Symbols: RNF73
Protein Interaction Partner: RAD18,UBE2A,UBE2B,HLTF,POLH,POLK,RAD51,SRRM2,TP53BP1,TSG101,UBE2A,UBE2B,UBE2I
Protein Size: 495 -
Molecular Weight
- 56 kDa
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Gene ID
- 56852
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NCBI Accession
- NM_020165, NP_064550
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UniProt
- Q9NS91
Target
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