Importin 5 (IPO5) (N-Term) Peptide
IPO5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Importin 5 (IPO5) products
- Importin 5 (IPO5)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GNNQWPEGLK FLFDSVSSQN VGLREAALHI FWNFPGIFGN QQQHYLDVIK
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RANBP5 Antibody(ARP53600_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Importin 5 (IPO5)
- Background
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Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
Alias Symbols: DKFZp686O1576, FLJ43041, IMB3, KPNB3, MGC2068, RANBP5, imp5
Protein Interaction Partner: HCVgp1,BHLHB9,DPPA3,H1F0,NUP153,NUP214,NUP62,NUP98,RAG2,RAN,RANBP2,RPL13,RPL23,RPL23A,RPL5,RPS7,BAP1,GABARAP,GABARAPL1,GABARAPL2,MEPCE,NUP153,NUP214,PMS1,RAN,RPL23A,SRP19,TAF1D,USP50
Protein Size: 1115 - Molecular Weight
- 125 kDa
- Gene ID
- 3843
- NCBI Accession
- NM_002271, NP_002262
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