Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (C-Term) Peptide
RASSF1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RASSF1 products
- RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LAGPSDKALS FVLKENDSGE VNWDAFSMPE LHNFLRILQR EEEEHLRQIL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RASSF1 Antibody(ARP59681_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
- Background
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This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: 123F2, NORE2A, RASSF1A, RDA32, REH3P21
Protein Interaction Partner: ATP2B4,MOAP1,TNFRSF10A,TNFRSF1A,ATP2B4,ATP2B4,ATP2B4,CDC20,CNKSR1,DAXX,E4F1,EXOSC8,HRAS,IGFBP5,MAP1B,MAP1S,MAPK8,MOAP1,NUDT10,RASSF1,RASSF5,STK4,TNFRSF10A,TNFRSF1A,TUBB,TUBG1,XPA,CNKSR1,DAXX,EXOSC8,HRAS,MAP1B,MAP1S,RASSF1,RASSF5,STK4,TUBB,TUBG1
Protein Size: 270 - Molecular Weight
- 30 kDa
- Gene ID
- 11186
- NCBI Accession
- NM_170713, NP_733831
- UniProt
- Q9NS23
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