Regulator of G-Protein Signalling 18 (RGS18) Peptide
RGS18
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RGS18 products
- RGS18 (Regulator of G-Protein Signalling 18 (RGS18))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RGS18 antibody (Catalog #: ARP42804_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Regulator of G-Protein Signalling 18 (RGS18) peptide
RGS18 Reactivity: Human Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RGS18 (Regulator of G-Protein Signalling 18 (RGS18))
- Background
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RGS18 is a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Alias Symbols: RP11-142L4.1, RGS13
Protein Interaction Partner: GNAI1,GNAI2,GNAI3,GNAQ,GNAI1,GNAI2,GNAI3,GNAQ
Protein Size: 235 - Molecular Weight
- 26 kDa
- Gene ID
- 64407
- NCBI Accession
- NM_130782, NP_570138
- UniProt
- Q9NS28
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