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Ras Homolog Gene Family, Member B (RHOB) (Middle Region) Peptide

RHOB Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN982961

Quick Overview for Ras Homolog Gene Family, Member B (RHOB) (Middle Region) Peptide (ABIN982961)

Target

RHOB (Ras Homolog Gene Family, Member B (RHOB))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Sequence

CPNVPIILVA NKKDLRSDEH VRTELARMKQ EPVRTDDGRA MAVRIQAYDY

Characteristics

This is a synthetic peptide designed for use in combination with anti-RHOB Antibody(ARP54702_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
Ras Homolog Gene Family, Member B (RHOB) peptide
RHOB Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

RHOB (Ras Homolog Gene Family, Member B (RHOB))

Background

RHOB mediates apoptosis in neoplastically transformed cells after DNA damage.RHOB is not essential for development but affects cell adhesion and growth factor signaling in transformed cells.RHOB plays a negative role in tumorigenesis as deletion causes tumor formation. RHOB is involved in intracellular protein trafficking of a number of proteins.RHOB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes.RHOB is also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.

Alias Symbols: ARH6, ARHB, MST081, MSTP081, RHOH6

Protein Interaction Partner: ARHGDIG,ARHGEF3,FNTA,PDE6D,PGGT1B,PPP2CA,RHPN2,ARHGDIG,ARHGEF3,CIT,PDE6D,RHPN2

Protein Size: 196

Molecular Weight

22 kDa

Gene ID

388

NCBI Accession

NM_004040, NP_004031

UniProt

P62745

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