Runt-Related Transcription Factor 2 (RUNX2) (N-Term) Peptide
RUNX2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983332
Quick Overview for Runt-Related Transcription Factor 2 (RUNX2) (N-Term) Peptide (ABIN983332)
Target
RUNX2
(Runt-Related Transcription Factor 2 (RUNX2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MRIPVDPSTS RRFSPPSSSL QPGKMSDVSP VVAAQQQQQQ QQQQQQQQQQ
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RUNX2 Antibody(ARP38452_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
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Background
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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.
Alias Symbols: AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1, OSF-2
Protein Interaction Partner: RB1,AR,AXIN1,CBFB,CCNB1,CDK1,CEBPB,DVL2,EP300,ETS1,FOS,HDAC3,HDAC4,HDAC6,JUN,LEF1,MAP3K4,MSX2,MYST4,PRKCD,RB1,SMAD2,SMAD3,SMAD6,TAF1A,UBTF,XRCC5,XRCC6,YAP1,BMPR1A,EP300,ETS1,FOS,HDAC1,HDAC3,HDAC4,HDAC5,HDAC6,HES1,JUN,KAT2B,LEF1,MSX2,MYST4,SMAD1,SMAD2,SMAD
Protein Size: 507 -
Molecular Weight
- 55 kDa
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Gene ID
- 860
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NCBI Accession
- NM_004348, NP_004339
Target
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