RuvB-Like 1 (E. Coli) (RUVBL1) Peptide
RUVBL1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983335
Quick Overview for RuvB-Like 1 (E. Coli) (RUVBL1) Peptide (ABIN983335)
Target
RUVBL1
(RuvB-Like 1 (E. Coli) (RUVBL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RUVBL1 antibody (Catalog #: ARP32349_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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Background
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RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Alias Symbols: ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
Protein Interaction Partner: CD82,KAT5,KLK3,ACTL6A,C20orf20,CTNNB1,KIAA1377,PLG,RUVBL2,TBP,ACTB,ACTG1,ACTL6A,C12orf45,C1orf57,C2orf44,CAPNS1,CCDC87,CDK9,CTNNB1,DDX42,DMAP1,DNASE2,DPCD,E2F7,ELAVL1,EP400,FDFT1,GNAS,GPN1,HLA-B,HSPA1L,HSPA8,ING3,KIAA1377,KPNB1,LEF1,MEPCE,MLH1,MYC,OFD1,PCBP1,PCBP2,PCBP3,PELO,PIH1D1,PMS2,PSTPIP1,RUVBL2,SMARCA2,SMNDC1,SRI,STAP1,TBP,TRRAP,TTI1,YEATS4
Protein Size: 456 -
Molecular Weight
- 50 kDa
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Gene ID
- 8607
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NCBI Accession
- NM_003707, NP_003698
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UniProt
- Q9Y265
Target
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