Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) Peptide
SF3B1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN983620
Quick Overview for Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) Peptide (ABIN983620)
Target
SF3B1
(Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SF3B1 antibody (Catalog #: ARP40249_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
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Background
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SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRP10, SAP155, SF3b155, MDS, Hsh155, PRPF10
Protein Interaction Partner: SF3B14,U2AF1,U2AF2,DYRK1A,MELK,PPP1R8,SF3B14,SF3B3,SMAD1,SMAD5,SMAD9,SNIP1,TCERG1,ATG12,BRF2,CCNE1,CDC5L,DDX42,GSK3B,HDAC3,PHF5A,PPP1R8,PUF60,RNPS1,RNU11,RNU12-2P,SAP130,SF3A2,SF3B14,SF3B2,SF3B3,SF3B4,SF3B5,SMNDC1,SNRNP40,TCERG1,YWHAZ
Protein Size: 1304 -
Molecular Weight
- 143 kDa
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Gene ID
- 23451
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NCBI Accession
- NM_012433, NP_036565
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UniProt
- O75533
Target
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