Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) (N-Term) Peptide
SF3B1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SF3B1 products
- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SF3B1 antibody (Catalog #: ARP40732_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
- Background
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SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRP10, PRPF10, SAP155, SF3b155, MDS, Hsh155
Protein Interaction Partner: SF3B14,U2AF1,U2AF2,DYRK1A,MELK,PPP1R8,SF3B14,SF3B3,SMAD1,SMAD5,SMAD9,SNIP1,TCERG1,ATG12,BRF2,CCNE1,CDC5L,DDX42,GSK3B,HDAC3,PHF5A,PPP1R8,PUF60,RNPS1,RNU11,RNU12-2P,SAP130,SF3A2,SF3B14,SF3B2,SF3B3,SF3B4,SF3B5,SMNDC1,SNRNP40,TCERG1,YWHAZ
Protein Size: 1304 - Molecular Weight
- 146 kDa
- Gene ID
- 23451
- NCBI Accession
- NM_012433, NP_036565
- UniProt
- O75533
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