Splicing Factor Proline/glutamine-Ric (SFPQ) Peptide
SFPQ
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all SFPQ products
- SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SFPQ antibody (Catalog #: ARP40572_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))
- Background
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SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.
Alias Symbols: PSF, POMP100
Protein Interaction Partner: NONO,TOP1,EXOSC5,FHL2,FUS,HN1,NONO,PSPC1,PTBP1,SFPQ,SFRS12,SIN3A,SMAD5,SNRPA,TOP1,UBB,ZMYM2,CDC5L,EXOSC5,FHL2,HDAC1,HDAC2,HN1,NONO,NR3C1,PTBP1,SFPQ,SIN3A,SP1,SP3,TOP1,UBC,ZMYM2
Protein Size: 707 - Molecular Weight
- 78 kDa
- Gene ID
- 6421
- NCBI Accession
- NM_005066, NP_005057
- UniProt
- P23246
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