SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide
SH2D1A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983683
Quick Overview for SH2 Domain Containing 1A (SH2D1A) (C-Term) Peptide (ABIN983683)
Target
SH2D1A
(SH2 Domain Containing 1A (SH2D1A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SH2D1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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Background
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: CD244,CD84,LY9,SLAMF1,SLAMF1,ARHGEF6,ARHGEF7,CD84,DOK1,FYB,FYN,GRB2,LCK,LY9,SLAMF1,SLAMF6,SLAMF7,CD244,CD84,DOK1,FYN,LY9,SLAMF1,SLAMF6
Protein Size: 128 -
Molecular Weight
- 14 kDa
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Gene ID
- 4068
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NCBI Accession
- NM_002351, NP_002342
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UniProt
- O60880
Target
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