SH2 Domain Containing 1A (SH2D1A) Peptide
SH2D1A
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all SH2D1A products
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of SH2 D2 antibody,
Alternative Names: SH2D1A control peptide, SH2D1A antibody Blocking Peptide, Anti-SH2D1A Blocking Peptide, SH2 domain protein 1A Blocking Peptide, DSHP Blocking Peptide, EBVS Blocking Peptide, FLJ18687 Blocking Peptide, FLJ92177 Blocking Peptide, IMD5 Blocking Peptide, LYP Blocking Peptide, MTCP1 Blocking Peptide, SAP Blocking Peptide, XLP Blocking Peptide, XLPD Blocking Peptide, SH2D1A, SHD1A-2, SHD1A 2, SHD1A-2 Blocking Peptide, SHD1A 2 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Synonyms
- DSHP Peptide, EBVS Peptide, IMD5 Peptide, LYP Peptide, MTCP1 Peptide, SAP Peptide, SAP/SH2D1A Peptide, XLP Peptide, XLPD Peptide, RGD1562408 Peptide, Gm686 Peptide, SH2D1A Peptide, SH2 domain containing 1A Peptide, SH2D1A Peptide, Sh2d1a Peptide
- Background
- SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
- Molecular Weight
- 14 kDa
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