E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Peptide
SIAH1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all SIAH1 products
- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SIAH1 antibody (Catalog #: ARP38212_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) peptide
SIAH1 Reactivity: Human, Rat, Cow, Dog, Mouse Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIAH1 (E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1))
- Background
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SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alias Symbols: SIAH1A
Protein Interaction Partner: DCC,DCC,UBE2I,UBE2I,AFF1,AFF4,APC,ATN1,BAG1,CACYBP,DAB1,DCC,EIF3J,GAPDH,HIPK3,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PKD1,POU2AF1,RBBP8,SH3RF1,SIAH1,SLC9A3R2,SNCAIP,SYP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBE2D1,AFF4,APC,BAG1,CACYBP,DAB1,DCC,HIF1AN,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PIAS1,PIAS2,PIAS3,POU2AF1,RBBP8,SIAH1,SYP,TBL1X,TRIB3,UBE2D1,UBE2E3,UBE2I,VAV1
Protein Size: 282 - Molecular Weight
- 31 kDa
- Gene ID
- 6477
- NCBI Accession
- NM_003031, NP_003022
- UniProt
- Q8IUQ4
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