Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Peptide
SIGLEC7
Reactivity: Human
Host: Synthetic
WB, BP
Catalog No. ABIN983743
$160.46
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100 μg
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Quick Overview for Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) Peptide (ABIN983743)
Target
SIGLEC7
(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB), Blocking Peptide (BP)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SIGLEC7 antibody (Catalog #: ARP47018_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
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Background
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SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Alias Symbols: AIRM1, CDw328, D-siglec, QA79, SIGLEC-7, p75, p75/AIRM1, CD328
Protein Interaction Partner: GRB2,PTPN11,TRAF4
Protein Size: 467 -
Molecular Weight
- 51 kDa
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Gene ID
- 27036
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NCBI Accession
- NM_014385, NP_055200
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UniProt
- Q9Y286
Target
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