Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200) (N-Term) Peptide
SNRNP200
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984189
Quick Overview for Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200) (N-Term) Peptide (ABIN984189)
Target
SNRNP200
(Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- GDEDVYGEVR EEASDDDMEG DEAVVRCTLS ANLVASGELM SSKKKDLHPR
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SNRNP200 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SNRNP200 (Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200))
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Background
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Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa.
Alias Symbols: ASCC3L1, BRR2, FLJ11521, HELIC2, RP33, U5-200KD
Protein Interaction Partner: CHMP1B,MEGF10,SMNDC1,YWHAB,YWHAG,APC,CD2BP2,MCC,MEPCE,MYC,PIN1,PRKAB1,RNPS1,RNU11,RNU12-2P,SMNDC1,SNRNP40,SNRPB,SRRM1,TCEA1,USP39,YWHAG,tat
Protein Size: 2136 -
Molecular Weight
- 244 kDa
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Gene ID
- 23020
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NCBI Accession
- NM_014014, NP_054733
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UniProt
- O75643
Target
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