Suppressor of Cytokine Signaling 1 (SOCS1) Peptide
SOCS1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN984226
Quick Overview for Suppressor of Cytokine Signaling 1 (SOCS1) Peptide (ABIN984226)
Target
SOCS1
(Suppressor of Cytokine Signaling 1 (SOCS1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SOCS1 antibody (Catalog #: ARP42147_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Suppressor of Cytokine Signaling 1 (SOCS1) peptide
SOCS1 Reactivity: Human, Cow, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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Background
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SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: AXL,CSF1R,FLT3,FYN,GRB2,IGF1R,INSR,ITK,KIT,NCK1,PDGFRB,PIK3R2,TEK,VAV1,VAV2,AXL,COMMD1,CSF1,CSF1R,CXCR4,EGFR,FLT3,FYN,GHR,GRB2,IFNGR1,IGF1R,IL2RB,INSR,IRS1,IRS2,ITK,JAK1,JAK2,JAK3,KIT,MPL,NCK1,PDGFRB,PIK3R1,PIK3R2,PIM2,RELA,TCEB1,TCEB2,TEC,TEK,TIRAP,TRIM8,VAV1,VAV2,ALK,COMMD1,CRK,CSF1R,EGFR,FLT3,FYN,GHR,GRB2,IGF1R,IL2RB,IRS1,IRS2,ITK,JAK2,KIT,MPL,NCK1,RELA,SOCS2,TCEB1,TCEB3,TEC,UBC,VAV1,VAV2
Protein Size: 211 -
Molecular Weight
- 23 kDa
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Gene ID
- 8651
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NCBI Accession
- NM_003745, NP_003736
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UniProt
- O15524
Target
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