Sortilin 1 (SORT1) (C-Term) Peptide
SORT1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Sortilin 1 (SORT1) products
- Sortilin 1 (SORT1)
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- YVCGGRFLVH RYSVLQQHAE ANGVDGVDAL DTASHTNKSG YHDDSDEDLL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SORT1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Sortilin 1 (SORT1)
- Synonyms
- SORT1 Peptide, 19.m02079 Peptide, gp95 Peptide, ldlcq6 Peptide, sortilin Peptide, Gp95 Peptide, LDLCQ6 Peptide, NT3 Peptide, 2900053A11Rik Peptide, AI852375 Peptide, Ntr3 Peptide, Ntsr3 Peptide, Nt3 Peptide, Nts3 Peptide, sort1 Peptide, zgc:85953 Peptide, sortilin 1 Peptide, sortilin Peptide, sortilin 1 S homeolog Peptide, sortilin 1a Peptide, SORT1 Peptide, TP01_0016 Peptide, BBOV_I002730 Peptide, sort1.S Peptide, Sort1 Peptide, sort1a Peptide
- Background
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This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes, however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p, the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
Alias Symbols: Gp95, NT3
Protein Interaction Partner: NGFR,SLC2A4,BDNF,GGA1,GGA2,LRPAP1,NGF,NGFR,NTS,CDK2,GGA1,GGA2,LRPAP1,NGF
Protein Size: 831 - Molecular Weight
- 84 kDa
- Gene ID
- 6272
- NCBI Accession
- NM_002959, NP_002950
- UniProt
- Q99523
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