Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (Middle Region) Peptide
SPG20
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984337
Quick Overview for Spastic Paraplegia 20 (Troyer Syndrome) (SPG20) (Middle Region) Peptide (ABIN984337)
Target
SPG20
(Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- ASWVSWGLVK GAEITGKAIQ KGASKLRERI QPEEKPVEVS PAVTKGLYIA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPG20 Antibody(ARP55162_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))
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Background
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This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Alias Symbols: KIAA0610, SPARTIN, TAHCCP1
Protein Interaction Partner: EPS15,SMURF2,TUBA1A,ZFYVE9,ITCH,TUBA1A
Protein Size: 666 -
Molecular Weight
- 73 kDa
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Gene ID
- 23111
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NCBI Accession
- NM_015087, NP_055902
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UniProt
- Q8N0X7
Target
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