Speckle-Type POZ Protein (SPOP-B) Peptide
SPOP-B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984367
Quick Overview for Speckle-Type POZ Protein (SPOP-B) Peptide (ABIN984367)
Target
SPOP-B
(Speckle-Type POZ Protein (SPOP-B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPOP antibody (Catalog #: ARP50348_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
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Background
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SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Alias Symbols: TEF2
Protein Interaction Partner: DDIT3,DPPA2,H2AFY,HCST,MYD88,PDX1,RTN3,RXRB,TRAF1,ZBTB16,DDIT3,DOK2,DPPA2,GDI1,KPNA6,MYD88,PIP5K1B,RTN3,RXRB,SIRT2,TRAF1,TRAF6,ZBTB16
Protein Size: 374 -
Molecular Weight
- 42 kDa
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Gene ID
- 8405
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NCBI Accession
- NM_001007226, NP_001007227
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UniProt
- O43791
Target
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