Speckle-Type POZ Protein (SPOP-B) Peptide
SPOP-B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SPOP-B products
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SPOP antibody (Catalog #: ARP50348_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
- Background
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SPOP may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Alias Symbols: TEF2
Protein Interaction Partner: DDIT3,DPPA2,H2AFY,HCST,MYD88,PDX1,RTN3,RXRB,TRAF1,ZBTB16,DDIT3,DOK2,DPPA2,GDI1,KPNA6,MYD88,PIP5K1B,RTN3,RXRB,SIRT2,TRAF1,TRAF6,ZBTB16
Protein Size: 374 - Molecular Weight
- 42 kDa
- Gene ID
- 8405
- NCBI Accession
- NM_001007226, NP_001007227
- UniProt
- O43791
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