Signal Transducer and Activator of Transcription 5A (STAT5A) Peptide
STAT5A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984531
Quick Overview for Signal Transducer and Activator of Transcription 5A (STAT5A) Peptide (ABIN984531)
Target
STAT5A
(Signal Transducer and Activator of Transcription 5A (STAT5A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-STAT5A antibody (Catalog #: ARP38256_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))
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Background
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STAT5A is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGF, STAT5
Protein Interaction Partner: CCND2,ESR1,IL5,IL9,NMI,STAT5A,BMX,BRCA1,BRCA2,BTK,CBL,CCR5,CD247,CEBPB,CENPJ,CRK,CRKL,CTLA4,EGFR,EP300,EPOR,ERBB4,ESR1,ESR2,GHR,IL2RB,IL2RG,IL7R,INSR,JAK1,JAK2,JAK3,KIT,LCK,MAGEA12,MAPK1,MAPK3,NCOR2,NMI,NR3C1,PDGFRA,PDGFRB,POU2F1,PPIB,PPP2CA,PRTFDC1,PTPN1,PTPN11,PTPN2,SHC1,SRC,STAP2,STAT1,STAT3,STAT5A,STAT5B,SYK,TEK,TSLP,BRCA1,BRCA2,CD247,CRKL,EGFR,EPOR,ERBB4,ESR1,ESR2,IL2RB,JAK1,JAK2,JAK3,MAGEA12,MAPK1,NMI,PRTFDC1,PTPN1,PTPN11,SHC1
Protein Size: 794 -
Molecular Weight
- 91 kDa
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Gene ID
- 6776
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NCBI Accession
- NM_003152, NP_003143
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UniProt
- P42229
Target
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