Signal Transducer and Activator of Transcription 5B (STAT5B) Peptide
STAT5B
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN984536
Quick Overview for Signal Transducer and Activator of Transcription 5B (STAT5B) Peptide (ABIN984536)
Target
STAT5B
(Signal Transducer and Activator of Transcription 5B (STAT5B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
-
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-STAT5B antibody (Catalog #: ARP39001_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
-
Background
-
STAT5B is a member of the STAT family of transcription factors. In response to cytokines andgrowth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: STAT5
Protein Interaction Partner: NMI,STAT5B,CBL,CD247,CENPJ,CRK,CRKL,CTLA4,CXCR4,EGFR,ELP2,EP300,EPOR,ERBB4,ETS1,ETS2,GHR,IL2RA,IL2RB,IL7R,INSR,JAK2,KIT,MAPK1,NCOR2,NMI,NR3C1,PDGFRA,PDGFRB,POU2F1,PPP2CA,PTPN1,PTPN11,PTPN2,PTPN6,RARA,SHC1,SRC,STAP2,STAT1,STAT3,STAT5A,STAT5B,TEK,CCR5,CD247,EGFR,ELP2,GHR,IL2RB,JAK1,JAK2,JAK3,NMI,NR3C1,PTPN1,PTPN11,PTPN6,SHC1
Protein Size: 787 -
Molecular Weight
- 90 kDa
-
Gene ID
- 6777
-
NCBI Accession
- NM_012448, NP_036580
-
UniProt
- P51692
Target
-
You are here:
