TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) Peptide
TANK
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984763
Quick Overview for TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) Peptide (ABIN984763)
Target
TANK
(TRAF Family Member-Associated NFKB Activator (TANK))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TANK antibody (Catalog #: ARP38421_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
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Background
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The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: I-TRAF, TRAF2
Protein Interaction Partner: CHUK,CHUK,IKBKE,IKBKG,CHUK,IKBKB,IKBKE,IKBKG,MAP4K5,TBK1,TRAF1,TRAF2,TRAF3,USP7,ZC3H12A,CHUK,IKBKE,IKBKG,IRF3,IRF7,ITGB1BP1,TBK1,TRAF1,TRAF2,TRAF3,TRIM37,Tbk1,UBC,ZC3H12A
Protein Size: 425 -
Molecular Weight
- 48 kDa
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Gene ID
- 10010
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NCBI Accession
- NM_004180, NP_004171
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UniProt
- Q92844
Target
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