Trichoplein, Keratin Filament Binding (TCHP) (C-Term) Peptide
TCHP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TCHP products
- TCHP (Trichoplein, Keratin Filament Binding (TCHP))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TCHP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TCHP (Trichoplein, Keratin Filament Binding (TCHP))
- Background
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TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Alias Symbols: MGC10854, TpMs
Protein Interaction Partner: CCDC85B,KRT14,KRT15,KRT16,KRT18,KRT5,KRT6A,KRT8,NME7,TEX11,VIM,CCDC85B,KRT15,NME7,TEX11,VIM
Protein Size: 498 - Molecular Weight
- 61 kDa
- Gene ID
- 84260
- NCBI Accession
- NM_032300, NP_115676
- UniProt
- Q9BT92
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