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Trichoplein, Keratin Filament Binding (TCHP) (C-Term) Peptide

TCHP Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN984916

Quick Overview for Trichoplein, Keratin Filament Binding (TCHP) (C-Term) Peptide (ABIN984916)

Target

TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

C-Term

Sequence

IQEKIEQNRR AQEESLKHRE QLIRNLEEVR ELARREKEES EKLKSARKQE

Characteristics

This is a synthetic peptide designed for use in combination with anti-TCHP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
Trichoplein, Keratin Filament Binding (TCHP) peptide
TCHP Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Background

TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.

Alias Symbols: MGC10854, TpMs

Protein Interaction Partner: CCDC85B,KRT14,KRT15,KRT16,KRT18,KRT5,KRT6A,KRT8,NME7,TEX11,VIM,CCDC85B,KRT15,NME7,TEX11,VIM

Protein Size: 498

Molecular Weight

61 kDa

Gene ID

84260

NCBI Accession

NM_032300, NP_115676

UniProt

Q9BT92

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