Transferrin Receptor (p90, CD71) (TFRC) (N-Term) Peptide
TFRC
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN985018
Quick Overview for Transferrin Receptor (p90, CD71) (TFRC) (N-Term) Peptide (ABIN985018)
Target
Transferrin Receptor (TFRC)
(Transferrin Receptor (p90, CD71) (TFRC))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Sequence
- GYLGYCKGVE PKTECERLAG TESPVREEPG EDFPAARRLY WDDLKRKLSE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TFRC Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Background
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TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Alias Symbols: CD71, TFR, TFR1, TRFR, T9, TR, p90
Protein Interaction Partner: ACAP1,TF,ACAP1,CD247,CD4,GABARAP,HFE,RAB5B,RANBP9,TF,TFRC,AI837181,AT5G46630,BST2,GABARAP,HDAC5,HFE,PXK,RYK,SVIP,TF,TFRC,nef
Protein Size: 760 -
Molecular Weight
- 84 kDa
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Gene ID
- 7037
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NCBI Accession
- NM_003234, NP_003225
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UniProt
- P02786
Target
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